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Therapeutic Benefit of Intravenous Administration of Bone Marrow Stromal Cells After Cerebral Ischemia in Rats

Stroke · 2001 · Vol. 32(4) · pp. 1005–1011
Jieli ChenYi LiLei WangZhenggang ZhangDunyue LuMei LüMichael Chopp

Abstract

MSCs delivered to ischemic brain tissue through an intravenous route provide therapeutic benefit after stroke. MSCs may provide a powerful autoplastic therapy for stroke.

Mesenchymal stem cell researchNeurogenesis and neuroplasticity mechanismsPluripotent Stem Cells ResearchMedicineMesenchymal stem cellBone marrowStroke (engine)IschemiaAnesthesiaBrain ischemiaStromal cellImmunohistochemistryPathology

MeSH terms

AnimalsBlood Gas AnalysisBrainCells, CulturedBrain IschemiaDisease Models, AnimalGraft SurvivalImmunoenzyme TechniquesImmunohistochemistryOrgan SpecificityPsychomotor PerformanceSeverity of Illness IndexBone Marrow TransplantationTreatment OutcomeStromal Cells

Funding

  • National Institute of Neurological Disorders and Stroke
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