article Open AccessTop 1% cited
Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression
BMC Cancer · 2013 · Vol. 13(1) · pp. 461–461
Kaihua Lu✉(Nanjing Medical University)Wei Li(Nanjing Medical University)Xiang-hua Liu(Nanjing Medical University)Ming Sun(Nanjing Medical University)Meiling Zhang(Nanjing Medical University)Weiqin Wu(Nanjing Medical University)Weiping Xie(Nanjing Medical University)Yayi Hou(Nanjing University)
Abstract
Our findings indicate that MEG3 is significantly down-regulated in NSCLC tissues that could be affected by DNA methylation, and regulates NSCLC cell proliferation and apoptosis, partially via the activition of p53. Thus, MEG3 may represent a new marker of poor prognosis and is a potential therapeutic target for NSCLC intervention.
Cancer-related molecular mechanisms researchCircular RNAs in diseasesRNA modifications and cancerLong non-coding RNASurgical oncologyApoptosisRNACancer researchCoding (social sciences)Cell growthOncologyInternal medicineCell biology
MeSH terms
AnimalsCarcinoma, Non-Small-Cell LungCell Transformation, NeoplasticDisease Models, AnimalFemaleHumansLung NeoplasmsLymphatic MetastasisMaleNeoplasm StagingGene Expression Regulation, NeoplasticTumor Suppressor Protein p53ApoptosisDNA MethylationCell Line, Tumor
Funding
- National Natural Science Foundation of China
- Priority Academic Program Development of Jiangsu Higher Education Institutions
Citations
436
FWCI
13.16
field-weighted impact
References
39
Percentile
99%
vs. same field & year
Citations per year
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