articleTop 1% cited
Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection
The American Journal of Gastroenterology · 2002 · Vol. 97(10) · pp. 2614–2618
Arie Regev✉Mariana Berho(Jackson Memorial Hospital)Lennox J. Jeffers(University of Miami)Clara Milikowski(Miami VA Healthcare System)Enrique Molina(University of Miami)Nikolaos Pyrsopoulos(University of Miami)Zheng-Zhou Feng(University of Miami)K. Rajender Reddy(University of Pennsylvania)Eugene R. Schiff(University of Miami)
Abstract
Liver biopsy samples taken from the right and left hepatic lobes differed in histological grading and staging in a large proportion of chronic hepatitis C virus patients; however, differences of more than one stage or grade were uncommon. A sampling error may have led to underdiagnosis of cirrhosis in 14.5% of the patients. These differences could not be attributed to intraobserver variation, which appeared to be low.
Liver Disease Diagnosis and TreatmentHepatitis C virus researchPancreatitis Pathology and TreatmentMedicineCirrhosisFibrosisLiver biopsyBiopsySampling (signal processing)Masson's trichrome stainGrading (engineering)PathologyGastroenterology
MeSH terms
AdultAgedBiopsy, NeedleFemaleFibrosisHumansInflammationLiverMaleMiddle AgedSpecimen HandlingObserver VariationHepatitis C, Chronic
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