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3D Bioprinting of Vascularized, Heterogeneous Cell‐Laden Tissue Constructs

Advanced Materials · 2014 · Vol. 26(19) · pp. 3124–3130
David B. KoleskyRyan L. TrubyA. Sydney GladmanTravis A. BusbeeKimberly A. HomanJennifer A. Lewis

Abstract

A new bioprinting method is reported for fabricating 3D tissue constructs replete with vasculature, multiple types of cells, and extracellular matrix. These intricate, heterogeneous structures are created by precisely co-printing multiple materials, known as bioinks, in three dimensions. These 3D micro-engineered environments open new -avenues for drug screening and fundamental studies of wound healing, angiogenesis, and stem-cell niches.

3D Printing in Biomedical ResearchInnovative Microfluidic and Catalytic Techniques InnovationPluripotent Stem Cells ResearchComputer scienceService (business)NanotechnologyTissue engineeringExtracellular matrixMaterials scienceDrug deliveryData scienceWorld Wide WebBiomedical engineering

MeSH terms

Extracellular MatrixHumansPolyethylene GlycolsPropylene GlycolsPoloxamerTissue EngineeringHuman Umbilical Vein Endothelial CellsBioprinting

Funding

  • Hansjörg Wyss Institute for Biologically Inspired Engineering, Harvard University
Citations
2,036
FWCI
96.91
field-weighted impact
References
36
Percentile
100%
vs. same field & year
Citations per year
References
Cell-laden microengineered gelatin methacrylate hydrogels
Biomaterials · 2010 · 2,316 citations
Organ printing: Tissue spheroids as building blocks
Biomaterials · 2009 · 1,224 citations
Endothelial cell functions
Journal of Cellular Physiology · 2003 · 754 citations
Porous scaffold design for tissue engineering
Nature Materials · 2005 · 3,868 citations
Scaffolds in tissue engineering bone and cartilage
Biomaterials · 2000 · 4,919 citations
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