articleTop 1% cited
Multipotent mesenchymal stem cells from adult human synovial membrane
Arthritis & Rheumatism · 2001 · Vol. 44(8) · pp. 1928–1942
Cosimo De Bari✉(KU Leuven)Francesco Dell’Accio(KU Leuven)Przemko Tylżanowski(KU Leuven)Frank P. Luyten(KU Leuven)
Abstract
Our study demonstrates that human multipotent MSCs can be isolated from the SM of knee joints. These cells have the ability to proliferate extensively in culture, and they maintain their multilineage differentiation potential in vitro, establishing their progenitor cell nature. SM-derived MSCs may play a role in the regenerative response during arthritic diseases and are promising candidates for developing novel cell-based therapeutic approaches for postnatal skeletal tissue repair.
Mesenchymal stem cell researchRNA Interference and Gene DeliveryTissue Engineering and Regenerative MedicineMesenchymal stem cellCell biologyMultipotent Stem CellBiologyStem cellCellular differentiationProgenitor cellCell cultureMolecular biologyImmunology
MeSH terms
AdolescentAdultAgedCell DifferentiationCells, CulturedClone CellsHumansMesodermMiddle AgedOsteocytesRNA, MessengerStem CellsSynovial MembraneBiomarkersCellular Senescence
Funding
- KU Leuven
Citations
1,821
FWCI
14.99
field-weighted impact
References
49
Percentile
99%
vs. same field & year
Citations per year
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