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Sulfoquinovosyldiacylglycerol, KM043, a New Potent Inhibitor of Eukaryotic DNA Polymerases and HIV-Reverse Transcriptase Type 1 from a Marine Red Alga, Gigartina tenella.
Chemical and Pharmaceutical Bulletin · 1998 · Vol. 46(4) · pp. 684–686
Keisuke Ohta✉(Tokyo University of Science)Y Mizushima(Tokyo University of Science)Noriko HirataMasaharu Takemura(Liberal Arts University)Fumio Sugawara(Tokyo University of Science)Akio Matsukage(Aichi Cancer Center)Shonen Yoshida(Nagoya University)Kengo Sakaguchi(Tokyo University of Science)
Abstract
A new sulfolipid, KM043, which belongs to the 6-sulfo-alpha-D-quinovopyranosyl-(1-->3')-1',2'-diacylglycerol (SQDG) class of compounds, has been isolated from a marine red alga, Gigartina tenella, as a potent inhibitor of eukaryotic DNA polymerases and HIV-reverse transcriptase type 1. Its structure was determined on the basis of spectroscopic and gas chromatographic analyses. The inhibition was dose-dependent, and complete (more than 90%) inhibition of DNA polymerase alpha (pol. alpha), DNA polymerase beta (pol. beta) and HIV-reverse transcriptase type 1 (HIV-RT) was observed at concentrations of 5, 10, and 30 microM, respectively.
Seaweed-derived Bioactive CompoundsEchinoderm biology and ecologyReverse transcriptaseDNA polymeraseChemistryPolymeraseMolecular biologyDNAEnzymeBiochemistryPolymerase chain reactionBiology
MeSH terms
RhodophytaChromatography, GasDiglyceridesGlycolipidsSpectrometry, Mass, Fast Atom BombardmentReverse Transcriptase InhibitorsNucleic Acid Synthesis InhibitorsHIV Reverse Transcriptase
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