article Open AccessTop 10% cited
PLEK: a tool for predicting long non-coding RNAs and messenger RNAs based on an improved k-mer scheme
BMC Bioinformatics · 2014 · Vol. 15(1) · pp. 311–311
Aimin Li✉(Xi’an University)Junying Zhang(Xidian University)Zhongyin Zhou(Chinese Academy of Sciences)
Abstract
PLEK is an efficient alignment-free computational tool to distinguish lncRNAs from mRNAs in RNA-seq transcriptomes of species lacking reference genomes. PLEK is especially suitable for PacBio or 454 sequencing data and large-scale transcriptome data. Its open-source software can be freely downloaded from https://sourceforge.net/projects/plek/files/.
Cancer-related molecular mechanisms researchGenomics and Phylogenetic StudiesRNA modifications and cancerComputational biologyRefSeqGene predictionTranscriptomeComputer scienceBiologyGeneGeneticsGenomeGene expression
MeSH terms
AlgorithmsAnimalsHumansProteinsRNA, MessengerSoftwareSequence Analysis, RNAComputational BiologyGene Expression ProfilingDatabases, GeneticMiceMolecular Sequence AnnotationSupport Vector MachineRNA, Long Noncoding
Funding
- National Natural Science Foundation of China
- Specialized Research Fund for the Doctoral Program of Higher Education of China
Citations
840
FWCI
5.99
field-weighted impact
References
59
Percentile
97%
vs. same field & year
Citations per year
References
RNA-Seq: a revolutionary tool for transcriptomics
Nature Reviews Genetics · 2008 · 13,223 citations
Rapid transcriptome characterization for a nonmodel organism using 454 pyrosequencing
Molecular Ecology · 2008 · 738 citations
Next-generation sequencing transforms today's biology
Nature Methods · 2007 · 1,798 citations
Long non-coding RNAs: insights into functions
Nature Reviews Genetics · 2009 · 5,773 citations
Long Noncoding RNA MALAT1 Controls Cell Cycle Progression by Regulating the Expression of Oncogenic Transcription Factor B-MYB
PLoS Genetics · 2013 · 770 citations
GENCODE: The reference human genome annotation for The ENCODE Project
Genome Research · 2012 · 5,001 citations
A tale of three next generation sequencing platforms: comparison of Ion torrent, pacific biosciences and illumina MiSeq sequencers
BMC Genomics · 2012 · 2,040 citations
Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences
Genome biology · 2010 · 3,516 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.
