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Acute and clinically relevant drug‐induced liver injury: a population based case‐control study

British Journal of Clinical Pharmacology · 2004 · Vol. 58(1) · pp. 71–80

Francisco J. de Abajo✉(Light Prescriptions Innovators (Spain))Dolores Montero(Pharmac)Mariano Madurga(Pharmac)Luis A. Garcı́a Rodrı́guez(Centro Español de Investigación Farmacoepidemiológica)

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Abstract

Idiopathic, acute and clinically relevant liver injury, which has the use of drugs as the most probable aetiology, is a rare event in the general population. The relative risks of 40 drugs/therapeutic classes are provided, along with the crude incidence rates for 15 of them where a statistical association was found.

Drug-Induced Hepatotoxicity and Protection Pharmacogenetics and Drug Metabolism Poisoning and overdose treatmentsMedicineOdds ratioPopulationFlucloxacillinConfidence intervalIncidence (geometry)Medical prescriptionPediatricsInternal medicinePharmacology

MeSH terms

Acute DiseaseAdolescentAdultAge FactorsAgedChildChild, PreschoolFemaleHumansMaleMiddle AgedRisk FactorsCase-Control StudiesChemical and Drug Induced Liver Injury

Citations

403

FWCI

8.08

field-weighted impact

References

Percentile

97%

vs. same field & year

Citations per year

Cited by

Burden of liver diseases in the world