Macrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug Discovery

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVPerspectiveNEXTMacrocycles Are Great Cycles: Applications, Opportunities, and Challenges of Synthetic Macrocycles in Drug DiscoveryEric Marsault*† and Mark L. Peterson*‡View Author Information† Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke Québec, J1H5N4, Canada‡ Tranzyme Pharma Inc., 3001 12e Avenue Nord, Sherbrooke, Québec, J1H5N4, Canada*For E.M.: phone, +819.820.6868, extension 12433; fax, +819.820.6841; e-mail, [email protected]. For M.L.P.: phone, +819.820.6845; fax, 819.820.6841; e-mail, [email protected]Cite this: J. Med. Chem. 2011, 54, 7, 1961–2004Publication Date (Web):March 7, 2011Publication History Received23 September 2010Published online7 March 2011Published inissue 14 April 2011https://pubs.acs.org/doi/10.1021/jm1012374https://doi.org/10.1021/jm1012374review-articleACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views18103Altmetric-Citations695LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Chemical structure,Inhibitors,Macrocycles,Macrocyclization,Peptides and proteins Get e-Alerts