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Proliferative Neural Stem Cells Have High Endogenous ROS Levels that Regulate Self-Renewal and Neurogenesis in a PI3K/Akt-Dependant Manner

Cell stem cell · 2011 · Vol. 8(1) · pp. 59–71

Janel E. Le Belle✉(University of California, Los Angeles)Nicolas M. Orozco(University of California, Los Angeles)Andres A. Paucar(University of California, Los Angeles)Jonathan P. Saxe(University of California, Los Angeles)Jack Mottahedeh(University of California, Los Angeles)April D. Pyle(University of California, Los Angeles)Hong Wu(University of California, Los Angeles)Harley I. Kornblum(University of California, Los Angeles)

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Neurogenesis and neuroplasticity mechanisms Neuroinflammation and Neurodegeneration Mechanisms Anesthesia and Neurotoxicity ResearchNeurogenesisNeural stem cellBiologyCell biologyPI3K/AKT/mTOR pathwayProgenitor cellReactive oxygen speciesStem cellProtein kinase BMultipotent Stem Cell

MeSH terms

AnimalsCells, CulturedHumansMice, Inbred StrainsSignal TransductionReactive Oxygen SpeciesPhosphatidylinositol 3-KinasesCell ProliferationProto-Oncogene Proteins c-aktMiceNeurogenesisNeural Stem Cells

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