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Presalvage prostate‐specific antigen (PSA) and PSA doubling time as predictors of biochemical failure of salvage cryotherapy in patients with locally recurrent prostate cancer after radiotherapy

Cancer · 2006 · Vol. 107(2) · pp. 275–280

Philippe E. Spiess(The University of Texas MD Anderson Cancer Center)Andrew K. Lee(The University of Texas MD Anderson Cancer Center)Dan Leibovici(The University of Texas MD Anderson Cancer Center)Xuemei Wang(The University of Texas MD Anderson Cancer Center)Kim‐Anh Do(The University of Texas MD Anderson Cancer Center)Louis L. Pisters✉(The University of Texas MD Anderson Cancer Center)

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Abstract

Presalvage PSA and PSA DT can predict biochemical failure of salvage cryotherapy, although the predictive value of PSA DT only trended toward significance. The statistically significant difference in pre- and postsalvage cryotherapy PSA DTs was reflective of aggressive tumor biology.

Prostate Cancer Diagnosis and Treatment Prostate Cancer Treatment and Research Effects of Radiation ExposureMedicineCryotherapyProstate-specific antigenProstate cancerRadiation therapyProportional hazards modelUrologyInternal medicineCancerStage (stratigraphy)

MeSH terms

AgedAged, 80 and overHumansMaleMiddle AgedNeoplasm Recurrence, LocalPrognosisProstatic NeoplasmsTime FactorsBiomarkers, TumorSalvage TherapyTreatment FailureProstate-Specific AntigenCryotherapy

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