reviewTop 1% cited
Recent advancements in surface-enhanced laser desorption/ionization-time of flight-mass spectrometry
Electrophoresis · 2000 · Vol. 21(6) · pp. 1164–1177
Maggie Merchant(Cipher Gene (China))Scot R. Weinberger✉
Abstract
The overall history and recent advances in surface enhanced laser desorption/ionization-time of flight-mass spectrometry (SELDI-TOF-MS) technology is reviewed herein. Fundamentals of SELDI-TOF analysis are presented while drawing comparisons with other laser-based mass spectrometry techniques. The application of SELDI-TOF-MS to functional genomics and biomarker discovery is discussed and exemplified by elucidating a biomarker candidate for prostatic carcinoma. Finally, a short discussion regarding future SELDI requirements and developments is supplied.
Mass Spectrometry Techniques and ApplicationsAdvanced Proteomics Techniques and ApplicationsAnalytical Chemistry and ChromatographyMass spectrometrySurface-enhanced laser desorption/ionizationBiomarker discoveryTime-of-flight mass spectrometryLaserBiomarkerChemistryDesorptionProteomicsChromatography
MeSH terms
HumansProteinsSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Citations
687
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35.14
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References
76
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100%
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References
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Electrospray ion source. Another variation on the free-jet theme
The Journal of Physical Chemistry · 1984 · 2,027 citations
Method to Correlate Tandem Mass Spectra of Modified Peptides to Amino Acid Sequences in the Protein Database
Analytical Chemistry · 1995 · 1,260 citations
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