articleTop 1% cited

Dopamine‐Melanin Colloidal Nanospheres: An Efficient Near‐Infrared Photothermal Therapeutic Agent for In Vivo Cancer Therapy

Advanced Materials · 2012 · Vol. 25(9) · pp. 1353–1359

Yanlan Liu(Changchun Institute of Applied Chemistry)Kelong Ai(Changchun Institute of Applied Chemistry)Jianhua Liu(Second Affiliated Hospital of Jilin University)Mo Deng(Second Affiliated Hospital of Jilin University)Yangyang He(Second Affiliated Hospital of Jilin University)Lehui Lu✉(Changchun Institute of Applied Chemistry)

View via DOI Publisher page

Abstract

A new generation of photothermal therapeutic agents based on biopolymer dopamine-melanin colloidal nanospheres is described. Benefitting from their naturally wide distribution in humans, dopamine-melanin colloidal nanospheres exhibit robust biocompatibility and biodegradability, and provide up to 40% photothermal conversion efficiency. After administration, they can efficiently damage tumors at low power density and short irradiation time without damaging healthy tissues.

Nanoplatforms for cancer theranostics Gold and Silver Nanoparticles Synthesis and Applications Extracellular vesicles in diseasePhotothermal therapyBiocompatibilityMaterials scienceMelaninNanotechnologyIn vivoBiopolymerColloidDopamineBiomedical engineering

MeSH terms

AnimalsAntineoplastic AgentsCell SurvivalColloidsDopamineDose-Response Relationship, DrugHeLa CellsHumansLasersMammary Neoplasms, ExperimentalMelaninsMice, Inbred BALB CParticle SizePhototherapyStructure-Activity Relationship