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Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients

BMJ · 2004 · Vol. 329(7456) · pp. 15–19

Munir Pirmohamed✉(University of Liverpool)Sally James(University of Liverpool)Shaun Meakin(University of Liverpool)Chris Green(University of Liverpool)Andrew Scott(University of Liverpool)Thomas Walley(Royal Liverpool University Hospital)Keith Farrar(Wirral University Teaching Hospital NHS Foundation Trust)B Kevin Park(Wirral University Teaching Hospital NHS Foundation Trust)Alasdair Breckenridge(Wirral University Teaching Hospital NHS Foundation Trust)

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Abstract

The burden of ADRs on the NHS is high, accounting for considerable morbidity, mortality, and extra costs. Although many of the implicated drugs have proved benefit, measures need to be put into place to reduce the burden of ADRs and thereby further improve the benefit:harm ratio of the drugs.

Pharmacovigilance and Adverse Drug Reactions Pharmaceutical Practices and Patient Outcomes Pharmaceutical studies and practicesMedicineProspective cohort studyWarfarinAspirinDrug reactionEmergency medicineDrugAdverse drug reactionObservational studyPediatrics

MeSH terms

AdolescentAdultAgedBed OccupancyEnglandFemaleHospitalizationHospitals, GeneralHumansMaleMiddle AgedPrognosisProspective StudiesPrevalenceHospital Costs

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Awareness, approach and application of pharmacovigilance: A questionnaire-based analysis in a tertiary care centre