articleTop 10% cited
Clinical pharmacology of buprenorphine: Ceiling effects at high doses
Clinical Pharmacology & Therapeutics · 1994 · Vol. 55(5) · pp. 569–580
Sharon Walsh✉(National Institute on Drug Abuse)Kenzie L. Preston(Johns Hopkins Medicine)Maxine L. Stitzer(Johns Hopkins Medicine)E. J. Cone(Johns Hopkins University)George E. Bigelow(Johns Hopkins Medicine)
Abstract
This study shows a plateau on buprenorphine effects, consistent with its partial agonist classification, and that single doses of buprenorphine up to 70 times the recommended analgesic dose are well tolerated by nondependent humans.
Pharmacological Receptor Mechanisms and EffectsAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesNeuropeptides and Animal PhysiologyBuprenorphineMedicinePartial agonistMethadoneAnesthesiaPharmacokineticsMiosisAgonistSedationOpioid
MeSH terms
Administration, SublingualAdultAnalysis of VarianceBuprenorphineHumansMaleMethadoneReference Values
Citations
765
FWCI
3.16
field-weighted impact
References
18
Percentile
93%
vs. same field & year
Citations per year
Cited by
Polydrug abuse: A review of opioid and benzodiazepine combination use
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References
Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man
Clinical Pharmacology & Therapeutics · 1971 · 958 citations
The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.
Journal of Pharmacology and Experimental Therapeutics · 1976 · 2,976 citations
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