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Stress doses of hydrocortisone reverse hyperdynamic septic shock

Critical Care Medicine · 1999 · Vol. 27(4) · pp. 723–732

Josef Briegel✉(Ludwig-Maximilians-Universität München)H. Forst(Ludwig-Maximilians-Universität München)Mathias Haller(Ludwig-Maximilians-Universität München)Gustav Schelling(Ludwig-Maximilians-Universität München)Erich Kilger(Ludwig-Maximilians-Universität München)G. Kuprat(Ludwig-Maximilians-Universität München)B. Hemmer(Ludwig-Maximilians-Universität München)Theresia Hummel(Ludwig-Maximilians-Universität München)Andreas Lenhart(Ludwig-Maximilians-Universität München)Mathias Heyduck(Ludwig-Maximilians-Universität München)Christian Stoll(Ludwig-Maximilians-Universität München)Klaus Peter(Ludwig-Maximilians-Universität München)

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Abstract

Infusion of stress doses of hydrocortisone reduced the time to cessation of vasopressor therapy in human septic shock. This was associated with a trend to earlier resolution of sepsis-induced organ dysfunctions. Overall shock reversal and mortality were not significantly different between the groups in this low-sized single-center study.

Sepsis Diagnosis and Treatment Adrenal Hormones and Disorders Electrolyte and hormonal disordersMedicineSeptic shockDobutamineAnesthesiaOrgan dysfunctionSepsisHydrocortisoneResuscitationInotropeNorepinephrine

MeSH terms

AdultAnti-Inflammatory AgentsCardiotonic AgentsDouble-Blind MethodDrug Administration ScheduleFemaleHemodynamicsHumansHydrocortisoneInfusions, IntravenousMaleMiddle AgedProspective StudiesShock, SepticVasoconstrictor Agents

Citations

896

FWCI

38.50

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

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