article Open AccessTop 1% cited
Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease
Neurobiology of Aging · 2014 · Vol. 35(8) · pp. 1792–1800
Michael B. Dinkins✉(Augusta University)Somsankar Dasgupta(Augusta University)Guanghu Wang(Georgia Regents Medical Center)Gu Zhu(Georgia Regents Medical Center)Erhard Bieberich(Georgia Regents Medical Center)
Extracellular vesicles in diseaseAlzheimer's disease research and treatmentsMicroRNA in disease regulationIn vivoAmyloid (mycology)ExosomeAlzheimer's diseaseReduction (mathematics)Diseaseβ amyloidPathologyAmyloid βMedicine
MeSH terms
Alzheimer DiseaseAniline CompoundsAnimalsAstrocytesBenzylidene CompoundsBrainCells, CulturedCeramidesDisease Models, AnimalFemaleMaleMice, Inbred C57BLPeptide FragmentsSphingomyelin PhosphodiesteraseAmyloid beta-Peptides
Funding
- National Institutes of Health
Citations
516
FWCI
11.10
field-weighted impact
References
59
Percentile
99%
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Citations per year
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References
Exosomes: Vehicles for the Transfer of Toxic Proteins Associated with Neurodegenerative Diseases?
Frontiers in Physiology · 2012 · 392 citations
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
Nature Cell Biology · 2008 · 4,954 citations
Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis
Journal of Cell Science · 2011 · 787 citations
Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation
Journal of Neuroscience · 2006 · 3,502 citations
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