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Serotype-Specific Differences in the Risk of Dengue Hemorrhagic Fever: An Analysis of Data Collected in Bangkok, Thailand from 1994 to 2006

PLoS neglected tropical diseases · 2010 · Vol. 4(3) · pp. e617–e617

Jessica R. Fried✉(Mahidol Oxford Tropical Medicine Research Unit)Robert V. Gibbons(Armed Forces Research Institute of Medical Science)Siripen Kalayanarooj(Queen Sirikit National Institute of Child Health)Stephen J. Thomas(Armed Forces Research Institute of Medical Science)Anon Srikiatkhachorn(University of Massachusetts Chan Medical School)In-Kyu Yoon(Armed Forces Research Institute of Medical Science)Richard G. Jarman(Armed Forces Research Institute of Medical Science)Sharone Green(University of Massachusetts Chan Medical School)Alan L. Rothman(University of Massachusetts Chan Medical School)Derek A. T. Cummings(Johns Hopkins University)

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Abstract

As in other studies, we find secondary disease to be strongly associated with DHF and with more severe grades of DHF. DENV-2 appears to be marginally associated with more severe dengue disease as evidenced by a significant association with DHF grade I when compared to DENV-1. In addition, we found non-significant trends with other grades of DHF. Restricting the analysis to secondary disease we found DENV-2 and -3 to be twice as likely to result in DHF as DEN-4. Differences in severity by study year may suggest that other factors besides serotype play a role in disease severity.

Mosquito-borne diseases and control Viral Infections and Vectors Malaria Research and ControlDengue feverDengue virusSerotypeMedicineOdds ratioSerologyDengue hemorrhagic feverInternal medicineUnivariate analysisEpidemiology