articleTop 1% cited

Randomized controlled trial of intraputamenal glial cell line–derived neurotrophic factor infusion in Parkinson disease

Annals of Neurology · 2006 · Vol. 59(3) · pp. 459–466

Anthony E. Lang✉(Toronto Western Hospital)Steven S. Gill(Frenchay Hospital)Nikunj K. Patel(Frenchay Hospital)Andrés M. Lozano(Toronto Western Hospital)John G. Nutt(Oregon Health & Science University)Richard D. Penn(University of Chicago)David J. Brooks(Hammersmith Hospital)Gary Hotton(Hammersmith Hospital)Elena Moro(Toronto Western Hospital)Peter Heywood(Toronto Western Hospital)Matthew Brodsky(Oregon Health & Science University)Kim J. Burchiel(Oregon Health & Science University)Patrick J. Kelly(New York University)Arif Dalvi(University of Chicago)B.L. Scott(Durham University)Mark Stacy(Duke University)Dennis A. Turner(Duke University)Virginia Wooten(University of Virginia)W. Jeff Elias(University of Virginia)Edward R. Laws(University of Virginia)Vijay Dhawan(IJ Research (United States))A. Jon Stoessl(University of British Columbia)James Matcham(Amgen (United Kingdom))Robert J. Coffey(Medtronic (United States))Michael Traub(Amgen (United States))

View via DOI Publisher page

Abstract

Liatermin did not confer the predetermined level of clinical benefit to patients with PD despite increased (18)F-dopa uptake. It is uncertain whether technical differences between this trial and positive open-label studies contributed in any way this negative outcome.

Nerve injury and regeneration Autism Spectrum Disorder Research Parkinson's Disease Mechanisms and TreatmentsGlial cell line-derived neurotrophic factorParkinson's diseaseDyskinesiaDopaminergicMedicineRandomized controlled trialPlaceboClinical endpointNeurotrophic factorsAnesthesia

MeSH terms

AdultAnalysis of VarianceDihydroxyphenylalanineDose-Response Relationship, DrugDouble-Blind MethodDrug EvaluationFemaleHumansMaleMiddle AgedParkinson DiseasePutamenRecombinant ProteinsSeverity of Illness IndexTime Factors

Citations

974

FWCI

27.32

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

Cited by

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy