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Predicting the risk of chemotherapy toxicity in older patients: The Chemotherapy Risk Assessment Scale for High‐Age Patients (CRASH) score

Cancer · 2011 · Vol. 118(13) · pp. 3377–3386

Martine Extermann✉(University of South Florida)I. Boler(Moffitt Cancer Center)Richard R. Reich(University of South Florida Sarasota–Manatee)Gary H. Lyman(Duke University)R. H. Brown(Sarasota Memorial Hospital)Joseph DeFelice(Morton Plant Hospital)Richard M. Levine(Medical Research Associates)Eric T. Lubiner(Fawcett Memorial Hospital)Pablo ReyesFrederic J. Schreiber(Watson Clinic)Lodovico Balducci(University of South Florida)

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Abstract

The CRASH score distinguished several risk levels of severe toxicity. The split score discriminated better than the combined score. To the authors' knowledge, this is the first score systematically integrating both chemotherapy and patient risk for older patients and has a potential for future clinical application.

Frailty in Older Adults Cancer survivorship and care Neutropenia and Cancer InfectionsMedicineCommon Terminology Criteria for Adverse EventsToxicityInternal medicineChemotherapyCohortRegimenCreatinineChemotherapy regimenProspective cohort study