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Rapid assessment of a novel series of selective CB2 agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis

Bioorganic & Medicinal Chemistry Letters · 2009 · Vol. 19(15) · pp. 4406–4409
Thomas RyckmansMartin P. EdwardsVal A. HorneAna Monica CorreiaDafydd R. OwenLisa R. ThompsonIsabelle TranMichelle F. TuttTim Young
Cannabis and Cannabinoid ResearchPharmacological Receptor Mechanisms and EffectsNeurotransmitter Receptor Influence on BehaviorChemistrySulfonamideStereochemistryAgonistChemical synthesisCombinatorial chemistryReceptorIn vitroBiochemistry
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References
Physiochemical drug properties associated with in vivo toxicological outcomes
Bioorganic & Medicinal Chemistry Letters · 2008 · 954 citations
The influence of drug-like concepts on decision-making in medicinal chemistry
Nature Reviews Drug Discovery · 2007 · 2,269 citations
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