review Open AccessTop 1% cited

The IGF‐1 receptor in cancer biology

International Journal of Cancer · 2003 · Vol. 107(6) · pp. 873–877

Renato Baserga✉(Sidney Kimmel Cancer Center)Francesca Peruzzi(Temple University)Krysztof Reiss(Temple University)

Abstract

The type 1 insulin-like growth factor receptor (IGF-1R) plays an important role in the establishment and maintenance of the transformed phenotype. It also has a strong antiapoptotic activity and has a significant influence on the control of cell and body size. Downregulation of the IGF-1R leads to massive apoptosis of cancer cells. These characteristics make it an attractive target for anticancer therapy.

Growth Hormone and Insulin-like Growth Factors Metabolism, Diabetes, and Cancer Cancer, Hypoxia, and MetabolismDownregulation and upregulationInsulin-like growth factorReceptorBiologyCancerPhenotypeInsulin-Like Growth Factor ReceptorApoptosisCancer cellCancer research

MeSH terms

AnimalsCell DivisionCell Transformation, NeoplasticHumansInsulin-Like Growth Factor IInsulin-Like Growth Factor IINeoplasmsPhosphoproteinsApoptosisReceptor, IGF Type 1MiceInsulin Receptor Substrate Proteins

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643

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Cited by

Insulin Receptor Isoforms and Insulin Receptor/Insulin-Like Growth Factor Receptor Hybrids in Physiology and Disease