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Detection of Circulating Tumor Cells in Peripheral Blood of Patients with Metastatic Breast Cancer: A Validation Study of the CellSearch System

Clinical Cancer Research · 2007 · Vol. 13(3) · pp. 920–928

Sabine Riethdorf✉(University Medical Center Hamburg-Eppendorf)Herbert A. Fritsche(The University of Texas MD Anderson Cancer Center)Volkmar Müller(University Medical Center Hamburg-Eppendorf)Thomas Rau(University Medical Center Hamburg-Eppendorf)Christian Schindlbeck(Ludwig-Maximilians-Universität München)Brigitte Rack(Ludwig-Maximilians-Universität München)Wolfgang Janni(Ludwig-Maximilians-Universität München)Cornelia Coith(University Medical Center Hamburg-Eppendorf)Katrin Beck(University Medical Center Hamburg-Eppendorf)F. Jänicke(University Medical Center Hamburg-Eppendorf)Summer Jackson(The University of Texas MD Anderson Cancer Center)Terrie G. Gornet(The University of Texas MD Anderson Cancer Center)Massimo Cristofanilli(The University of Texas MD Anderson Cancer Center)Klaus Pantel(Universität Hamburg)

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Abstract

The CellSearch system enables the reliable detection of CTCs in blood and is suitable for the routine assessment of metastatic breast cancer patients in the clinical laboratory. Blood samples should be shipped at room temperature and CTC counts are stable for at least 72 h.

Cancer Cells and Metastasis Microfluidic and Bio-sensing Technologies Cancer Genomics and DiagnosticsCirculating tumor cellMetastatic breast cancerBreast cancerMedicineCancerPeripheral bloodOncologyInternal medicineMetastasisProspective cohort study

MeSH terms

Breast NeoplasmsCells, CulturedClinical Trials as TopicFemaleHumansNeoplastic Cells, CirculatingNeoplasm MetastasisPrognosisProspective StudiesTemperatureTime FactorsReproducibility of ResultsMulticenter Studies as TopicCell Culture Techniques

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