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Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
Endocrine Reviews · 2001 · Vol. 22(2) · pp. 153–183
Gray W. Pearson✉(The University of Texas Southwestern Medical Center)Fred L. Robinson(The University of Texas Southwestern Medical Center)Tara Beers Gibson(The University of Texas Southwestern Medical Center)Bing-e Xu(The University of Texas Southwestern Medical Center)Mahesh Karandikar(The University of Texas Southwestern Medical Center)Kevin Berman(The University of Texas Southwestern Medical Center)Melanie H. Cobb(The University of Texas Southwestern Medical Center)
Abstract
Mitogen-activated protein (MAP) kinases comprise a family of ubiquitous proline-directed, protein-serine/threonine kinases, which participate in signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. MAP kinases lie in protein kinase cascades. This review discusses the regulation and functions of mammalian MAP kinases. Nonenzymatic mechanisms that impact MAP kinase functions and findings from gene disruption studies are highlighted. Particular emphasis is on ERK1/2.
Melanoma and MAPK PathwaysProtein Kinase Regulation and GTPase SignalingCytokine Signaling Pathways and InteractionsMitogen-activated protein kinaseASK1KinaseMAPK14c-RafMAP2K7MAPK7Cell biologySignal transductionMAP kinase kinase kinase
MeSH terms
AnimalsHumansPhosphorylationMitogen-Activated Protein KinasesMAP Kinase Signaling System
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