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A New Formula for Depigmenting Human Skin

Archives of Dermatology · 1975 · Vol. 111(1) · pp. 40–40

Abstract

Complete depigmentation of the noraml skin of adult male blacks was procured by the daily application for five to seven weeks of a formula consisting of 0.1% tretinoin, 5.0% hydroquinone, 0.1% dexamethasone, and hydrophilic ointment. Depigmentation was not attainable when any one of the components was omitted. The formula was therapeutically effective in treatment of melasma, ephelides, and postinflammatory hyperpigmentation. Senile lentigines were resistant to this therapy.

Dermatologic Treatments and Research Acne and Rosacea Treatments and Effects melanin and skin pigmentationDepigmentationMedicineDermatologyMelasmaHyperpigmentation

MeSH terms

Administration, TopicalDexamethasoneDose-Response Relationship, DrugDrug EvaluationDrug Therapy, CombinationHumansHydrocortisoneHydroquinonesKeratolytic AgentsMaleOcclusive DressingsPigmentation DisordersSkinUltraviolet RaysVitamin A

Citations

425

FWCI

2.83

field-weighted impact

References

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91%

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Cited by

Topical Retinoic Acid (Tretinoin) for Melasma in Black Patients