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Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood

Nature Medicine · 2007 · Vol. 13(4) · pp. 463–469
Stephen ClarkC. AdrienneSamantha A. TavenerBraedon McDonaldZahra GoodarziMargaret M. KellyKamala D. PatelSubhadeep ChakrabartiErin F. McAvoyGary SinclairElizabeth KeysEmma Allen‐VercoeRebekah DeVinneyChristopher J. DoigFrancis H. Y. GreenPaul Kubes
Neutrophil, Myeloperoxidase and Oxidative MechanismsBlood disorders and treatmentsSepsis Diagnosis and TreatmentNeutrophil extracellular trapsTLR4PlateletSepsisExtracellularImmunologyPlatelet activationPathogenesisBacteriaSeptic shock

MeSH terms

Alanine TransaminaseAnimalsBacteriaBlood PlateletsEpitheliumHumansLipopolysaccharidesLiverNeutrophilsSepsisToll-Like Receptor 4Mice
Citations
2,219
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16.07
field-weighted impact
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References
Neutrophil Extracellular Traps Kill Bacteria
Science · 2004 · 9,872 citations
Novel cell death program leads to neutrophil extracellular traps
The Journal of Cell Biology · 2007 · 3,097 citations
HOW NEUTROPHILS KILL MICROBES
Annual Review of Immunology · 2005 · 1,762 citations
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