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A PPARγ-LXR-ABCA1 Pathway in Macrophages Is Involved in Cholesterol Efflux and Atherogenesis

Molecular Cell · 2001 · Vol. 7(1) · pp. 161–171

Ajay Chawla✉(Salk Institute for Biological Studies)William A. Boisvert(University of California, Los Angeles)Chih‐Hao Lee(Salk Institute for Biological Studies)Bryan Laffitte(Howard Hughes Medical Institute)Yaacov Barak(Salk Institute for Biological Studies)Sean B. Joseph(Howard Hughes Medical Institute)Debbie Liao(Howard Hughes Medical Institute)László Nagy(University of Debrecen)Peter A. Edwards(University of California, Los Angeles)Linda K. Curtiss(Scripps Research Institute)Ronald M. Evans(Howard Hughes Medical Institute)Peter Tontonoz(Howard Hughes Medical Institute)

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Cholesterol and Lipid Metabolism Peroxisome Proliferator-Activated Receptors Cancer, Lipids, and MetabolismABCA1CD36Liver X receptorBiologyPeroxisome proliferator-activated receptorCholesterolCell biologyReverse cholesterol transportNuclear receptorLipoprotein

MeSH terms

Liver X ReceptorsAnimalsArteriosclerosisCells, CulturedDNA-Binding ProteinsLipoproteins, LDLCholesterol, LDLMacrophagesMice, Inbred C57BLTranscription FactorsTranscriptional ActivationBone Marrow TransplantationReceptors, Cytoplasmic and NuclearMice, KnockoutATP-Binding Cassette Transporters

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