article Open AccessTop 1% cited
Generation of Breast Cancer Stem Cells through Epithelial-Mesenchymal Transition
PLoS ONE · 2008 · Vol. 3(8) · pp. e2888–e2888
Anne‐Pierre Morel(Centre Léon Bérard)Marjory Lièvre(Centre Léon Bérard)Clémence Thomas(Inserm)George Hinkal(Centre de Recherche en Cancérologie de Lyon)Stéphane Ansieau(Centre de Recherche en Cancérologie de Lyon)Alain Puisieux✉(Centre de Recherche en Cancérologie de Lyon)
Abstract
Recently, two novel concepts have emerged in cancer biology: the role of so-called "cancer stem cells" in tumor initiation, and the involvement of an epithelial-mesenchymal transition (EMT) in the metastatic dissemination of epithelial cancer cells. Using a mammary tumor progression model, we show that cells possessing both stem and tumorigenic characteristics of "cancer stem cells" can be derived from human mammary epithelial cells following the activation of the Ras-MAPK pathway. The acquisition of these stem and tumorigenic characters is driven by EMT induction.
Cancer Cells and MetastasisFOXO transcription factor regulationCancer Genomics and DiagnosticsEpithelial–mesenchymal transitionCancer stem cellStem cellCancer researchCancerBiologyMesenchymal stem cellCancer cellBreast cancerMetastasis
MeSH terms
BreastBreast NeoplasmsCell DivisionColony-Forming Units AssayEpithelial CellsFemaleFlow CytometryHumansMesodermNeoplasm MetastasisRetroviridaeStem CellsTumor Cells, CulturedHyaluronan ReceptorsCD24 Antigen
Funding
- Breast Cancer Research Foundation
- Ligue Contre le Cancer
- Institut National Du Cancer
Citations
1,613
FWCI
33.51
field-weighted impact
References
41
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100%
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