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A New Group of Chromatin‐Associated Proteins with a High Content of Acidic and Basic Amino Acids

European Journal of Biochemistry · 1973 · Vol. 38(1) · pp. 14–19

Graham H. Goodwin✉(Institute of Cancer Research)Clive Sanders(Institute of Cancer Research)Ernest W. Johns(Institute of Cancer Research)

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Abstract

A new group of chromatin‐associated proteins having a high content of acidic and basic amino acids have been isolated from the 0.35 M NaCl‐extractable proteins from calf thymus. This new group, designated “high‐mobility group” proteins have been partially separated and some interesting new proteins identified. One such protein contains over 55% acidic and basic amino acids.

Peptidase Inhibition and Analysis Cancer-related gene regulation Ubiquitin and proteasome pathwaysAmino acidChromatinHigh-mobility groupBiochemistryGroup (periodic table)ChemistryNon-histone proteinBiologyDNAOrganic chemistry

MeSH terms

Amino AcidsAnimalsCattleChromatinChromatography, GelElectrophoresis, Polyacrylamide GelChemical PrecipitationProteinsSodium ChlorideSolubilityThymus GlandTrichloroacetic AcidUrea

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