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Bidirectional signaling between the cytoskeleton and integrins

Current Opinion in Cell Biology · 1999 · Vol. 11(2) · pp. 274–286

Simone M. Schoenwaelder✉(University of North Carolina at Chapel Hill)Keith Burridge✉(University of North Carolina at Chapel Hill)

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Cellular Mechanics and Interactions Cell Adhesion Molecules Research Skin and Cellular Biology ResearchFocal adhesionCell biologyBiologyLamellipodiumIntegrinFilopodiaActin cytoskeletonCytoskeletonGTPaseActin

MeSH terms

ActinsCyclic AMPAnimalsCell AdhesionCytoskeletonHumansIntermediate FilamentsMicrotubulesModels, BiologicalPhosphorylationProtein Processing, Post-TranslationalOrganellesSignal TransductionIntegrinsExtracellular Matrix Proteins

Funding

National Institutes of Health
National Health and Medical Research Council
National Medical Research Council

Citations

759

FWCI

31.02

field-weighted impact

References

159

Percentile

100%

vs. same field & year

Citations per year

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References

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The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

Cell · 1992 · 4,468 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

Cell · 1995 · 4,399 citations

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

Journal of Biological Chemistry · 1998 · 3,080 citations

Rho GTPases and signaling networks

Genes & Development · 1997 · 2,378 citations

The p160 RhoA-Binding Kinase ROKα Is a Member of a Kinase Family and Is Involved in the Reorganization of the Cytoskeleton

Molecular and Cellular Biology · 1996 · 878 citations

Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton

The EMBO Journal · 1999 · 1,554 citations

Molecular and Cellular Biology · 1995 · 1,018 citations

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