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Prognostic Role of Neutrophil-to-Lymphocyte Ratio in Solid Tumors: A Systematic Review and Meta-Analysis
JNCI Journal of the National Cancer Institute · 2014 · Vol. 106(6) · pp. dju124–dju124
Arnoud J. Templeton✉(University of Alabama at Birmingham)Mairéad G. McNamara(Princess Margaret Cancer Centre)Boštjan Šeruga(Institute of Oncology Ljubljana)Francisco Vera-Badillo(Hospital General Universitario de Albacete)Priya Aneja(Hospital General Universitario de Albacete)Alberto Ocaña(Institute of Oncology Ljubljana)Raya Leibowitz‐Amit(Princess Margaret Cancer Centre)Guru Sonpavde(Princess Margaret Cancer Centre)Jennifer J. Knox(Institute of Oncology Ljubljana)Ben Tran(University of Toronto)Ian F. Tannock(University of Toronto)Eitan Amir(University of Toronto)
Abstract
A high NLR is associated with an adverse OS in many solid tumors. The NLR is a readily available and inexpensive biomarker, and its addition to established prognostic scores for clinical decision making warrants further investigation.
Inflammatory Biomarkers in Disease PrognosisCancer, Lipids, and MetabolismPancreatic and Hepatic Oncology ResearchHazard ratioMedicineInternal medicineMeta-analysisNeutrophil to lymphocyte ratioOncologyConfidence intervalBiomarkerCutoffLymphocyte
MeSH terms
HumansLymphocytesNeoplasmsNeutrophilsPredictive Value of TestsPrognosisSensitivity and SpecificitySurvival RateOdds RatioTreatment OutcomeDisease-Free SurvivalLymphocyte Count
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References
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The American Journal of Surgery · 2008 · 457 citations
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BMC Cancer · 2013 · 372 citations
Elevated Preoperative Neutrophil:Lymphocyte Ratio as a Predictor of Postoperative Disease Recurrence in Esophageal Cancer
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Preoperative Neutrophil‐to‐Lymphocyte Ratio as a Prognostic Predictor after Curative Resection for Hepatocellular Carcinoma
World Journal of Surgery · 2008 · 400 citations
Usefulness of the Neutrophil-to-Lymphocyte Ratio in Predicting Short- and Long-Term Mortality in Breast Cancer Patients
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