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Pd(PhCN)<sub>2</sub>Cl<sub>2</sub>/P(<i>t</i>-Bu)<sub>3</sub>: A Versatile Catalyst for Sonogashira Reactions of Aryl Bromides at Room Temperature
Organic Letters · 2000 · Vol. 2(12) · pp. 1729–1731
Thomas Hundertmark✉(Massachusetts Institute of Technology)Adam F. Littke(Massachusetts Institute of Technology)Stephen L. Buchwald(Massachusetts Institute of Technology)Gregory C. Fu(Massachusetts Institute of Technology)
Abstract
[reaction: see text] Pd(PhCN)(2)Cl(2)/P(t-Bu)(3) serves as an efficient and a versatile catalyst for room-temperature Sonogashira reactions of aryl bromides.
Catalytic Cross-Coupling ReactionsCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsChemistryArylSonogashira couplingCatalysisMedicinal chemistryCombinatorial chemistryOrganic chemistryPalladium
MeSH terms
AlkynesBromobenzenesCatalysisOrganometallic CompoundsPalladiumTemperature
Citations
425
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18.54
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References
9
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References
Palladium catalyzed synthesis of aryl, heterocyclic and vinylic acetylene derivatives
Journal of Organometallic Chemistry · 1975 · 730 citations
Synthesis of aryl- and vinyl-substituted acetylene derivatives by the use of nickel and palladium complexes
Journal of Organometallic Chemistry · 1975 · 575 citations
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