articleTop 1% cited
Human epithelial β-defensins 2 and 3 inhibit HIV-1 replication
AIDS · 2003 · Vol. 17(16) · pp. F39–F48
Miguel E. Quiñones‐Mateu(Cleveland Clinic)Michael M. Lederman(Johns Hopkins University Center for AIDS Research)Zhimin FengBikram Chakraborty(Cleveland Clinic)Jan Weber(Cleveland Clinic)Héctor R. Rangel(Cleveland Clinic)Michael Marotta(Cleveland Clinic)Muneer Mirza(Cleveland Clinic)Bin JiangPatti Kiser(Cleveland Clinic)Kathy Medvik(Johns Hopkins University Center for AIDS Research)Scott F. Sieg(Johns Hopkins University Center for AIDS Research)Aaron Weinberg✉(Johns Hopkins University Center for AIDS Research)
Abstract
This study shows for the first time that HIV-1 induces beta-defensin expression in human oral epithelial cells and that beta-defensins block HIV-1 replication via a direct interaction with virions and through modulation of the CXCR4 coreceptor. These properties may be exploited as strategies for mucosal protection against HIV-1 transmission.
Antimicrobial Peptides and ActivitiesHIV Research and TreatmentHerpesvirus Infections and TreatmentsFlow cytometryBeta defensinInfectivityDefensinBiologyViral replicationVirologyPeripheral blood mononuclear cellConfocal microscopyCXCR4
MeSH terms
Cells, CulturedDose-Response Relationship, DrugEpithelial CellsGene Expression RegulationHumansMouth MucosaRecombinant ProteinsRNA, MessengerVirus ReplicationHIV-1Receptors, CCR5Receptors, CXCR4beta-Defensins
Citations
417
FWCI
13.62
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References
48
Percentile
99%
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