article Open AccessTop 1% cited
Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer
British Journal of Cancer · 2009 · Vol. 100(10) · pp. 1603–1607
Jonas Nilsson✉(Umeå University)Johan Skog(Massachusetts General Hospital)Annika Nordstrand(Umeå University)Vladimir Baranov(Umeå University)Lucia Mincheva‐Nilsson(Umeå University)Xandra O. Breakefield(Massachusetts General Hospital)Anders Widmark(Umeå University)
Abstract
Herein, we describe a novel approach in the search for prostate cancer biomarkers, which relies on the transcriptome within tumour exosomes. As a proof-of-concept, we show the presence of two known prostate cancer biomarkers, PCA-3 and TMPRSS2:ERG the in exosomes isolated from urine of patients, showing the potential for diagnosis and monitoring cancer patients status.
Extracellular vesicles in diseaseProstate Cancer Treatment and ResearchCancer-related molecular mechanisms researchProstate cancerMicrovesiclesCancerMedicineProstatePCA3BiomarkerBiomarker discoveryCancer biomarkersTMPRSS2
MeSH terms
Antigens, NeoplasmHumansMaleProstatic NeoplasmsRNA, MessengerBiomarkers, TumorOncogene Proteins, FusionUrinalysisExosomes
Funding
- National Cancer Institute
Citations
777
FWCI
11.43
field-weighted impact
References
20
Percentile
99%
vs. same field & year
Citations per year
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References
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