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AUTISM IN THALIDOMIDE EMBRYOPATHY: A POPULATION STUDY

Developmental Medicine & Child Neurology · 1994 · Vol. 36(4) · pp. 351–356

Kerstin Strömland✉(American Academy of Child and Adolescent Psychiatry)Viviann Nordin(American Academy of Child and Adolescent Psychiatry)Marilyn T. Miller(University of Illinois Chicago)Bengt Åkerström(Östersunds Hospital)Christopher Gillberg(University of Gothenburg)

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Abstract

Of a population of 100 Swedish thalidomide embryopathy cases, at least four met full criteria for DSM-III-R autistic disorder and ICD-10 childhood autism. Thalidomide embryopathy of the kind encountered in these cases affects fetal development early in pregnancy, probably on days 20 to 24 after conception. It is argued that the possible association of thalidomide embryopathy with autism may shed some light on the issue of which neural circuitries may be involved in autism pathogenesis.

Autism Spectrum Disorder Research Prenatal Screening and Diagnostics Genomic variations and chromosomal abnormalitiesThalidomideAutismPopulationPhilosophyGynecologyPsychologyHumanitiesMedicinePsychiatryImmunology