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The purines: Potent and versatile small molecule inhibitors and modulators of key biological targets

Bioorganic & Medicinal Chemistry · 2006 · Vol. 14(12) · pp. 3987–4006
Michel Legraverend✉David S. Grierson
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Biochemical and Molecular ResearchSynthesis and Biological EvaluationBioactive Compounds and Antitumor AgentsPurineChemistrySmall moleculePurine metabolismBiochemistryDrug discoveryAdenosine receptorComputational biologyReceptorBiology

MeSH terms

Antiviral AgentsCell DifferentiationEnzyme InhibitorsHumansLigandsPurinesStructure-Activity RelationshipMolecular Structure
Citations
325
FWCI
7.33
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References
165
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98%
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References
Inhibition of Cyclin‐Dependent Kinases by Purine Analogues
European Journal of Biochemistry · 1997 · 717 citations
The specificities of protein kinase inhibitors: an update
Biochemical Journal · 2003 · 1,355 citations
Adenosine receptors: new opportunities for future drugs
Bioorganic & Medicinal Chemistry · 1998 · 279 citations
Inhibition of Cyclin‐Dependent Kinases by Purine Analogues
European Journal of Biochemistry · 1994 · 625 citations
Biochemical and Cellular Effects of Roscovitine, a Potent and Selective Inhibitor of the Cyclin‐Dependent Kinases cdc2, cdk2 and cdk5
European Journal of Biochemistry · 1997 · 1,349 citations
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