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An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

Developmental Cell · 2014 · Vol. 31(6) · pp. 722–733
Marco DemariaNaoko OhtaniSameh A. YoussefFrançis RodierWendy ToussaintJames R. MitchellRémi-Martin LabergeJan VijgHarry van SteegMartijn E.T. DolléJan H.J. HoeijmakersAlain de BruinEiji HaraJudith Campisi
Telomeres, Telomerase, and SenescenceWound Healing and TreatmentsNeutrophil, Myeloperoxidase and Oxidative MechanismsBiologyWound healingPlatelet-derived growth factor receptorSenescencePhenotypeSecretionMyofibroblastPlatelet-derived growth factorCell biologyGrowth factor

MeSH terms

AnimalsCell DifferentiationFemaleFibroblastsMaleMesodermMice, TransgenicPlatelet-Derived Growth FactorWound HealingCellular SenescenceApoptosisTransgenesEndothelial CellsLuminescenceMice

Funding

  • American-Italian Cancer Foundation
  • National Institutes of Health
  • Japan Science and Technology Agency
Citations
1,916
FWCI
36.63
field-weighted impact
References
47
Percentile
100%
vs. same field & year
Citations per year
References
Factors Affecting Wound Healing
Journal of Dental Research · 2010 · 5,453 citations
The serial cultivation of human diploid cell strains
Experimental Cell Research · 1961 · 8,329 citations
Myofibroblasts and mechano-regulation of connective tissue remodelling
Nature Reviews Molecular Cell Biology · 2002 · 4,182 citations
The myofibroblast in wound healing and fibrocontractive diseases
The Journal of Pathology · 2003 · 1,598 citations
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Proceedings of the National Academy of Sciences · 1995 · 7,364 citations
Lamin B1 loss is a senescence-associated biomarker
Molecular Biology of the Cell · 2012 · 989 citations
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