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Neurobiological substrates for the dark side of compulsivity in addiction

Neuropharmacology · 2008 · Vol. 56 · pp. 18–31
George F. Koob
Neurotransmitter Receptor Influence on BehaviorReceptor Mechanisms and SignalingNeuropeptides and Animal PhysiologyExtended amygdalaNeurochemicalPsychologyAmygdalaAddictionNeuroscienceReward systemImpulsivityCentral nucleus of the amygdalaStriatum

MeSH terms

AnimalsCompulsive BehaviorCorticotropin-Releasing HormoneHumansMotivationNeurobiologyReinforcement, PsychologyRewardSelf AdministrationSubstance-Related Disorders

Funding

  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases
Citations
451
FWCI
11.29
field-weighted impact
References
159
Percentile
99%
vs. same field & year
Citations per year
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References
Allostasis and Allostatic Load Implications for Neuropsychopharmacology
Neuropsychopharmacology · 2000 · 1,799 citations
Drug Addiction, Dysregulation of Reward, and Allostasis
Neuropsychopharmacology · 2001 · 2,922 citations
Drugs of abuse: anatomy, pharmacology and function of reward pathways
Trends in Pharmacological Sciences · 1992 · 2,088 citations
Handbook of Life Stress, Cognition and Health
American Journal of Psychiatry · 1989 · 1,411 citations
Molecular basis of long-term plasticity underlying addiction
Nature reviews. Neuroscience · 2001 · 1,855 citations
Impaired inhibitory control of behavior in chronic cocaine users
Drug and Alcohol Dependence · 2002 · 521 citations
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