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Lower tidal volume strategy (≈3 ml/kg) combined with extracorporeal CO2 removal versus ‘conventional’ protective ventilation (6 ml/kg) in severe ARDS

Intensive Care Medicine · 2013 · Vol. 39(5) · pp. 847–856
Thomas BeinSteffen Weber‐CarstensAnton GoldmannThomas MüllerThomas StaudingerJörg BrederlauRalf M. MuellenbachRolf DembinskiBernhard GräfMarlene WewalkaAlois PhilippKlaus‐Dieter WerneckeMatthias LubnowArthur S. Slutsky

Abstract

The use of very low V(T) combined with extracorporeal CO2 removal has the potential to further reduce VILI compared with a 'normal' lung protective management. Whether this strategy will improve survival in ARDS patients remains to be determined (Clinical trials NCT 00538928).

Respiratory Support and MechanismsCardiac Arrest and ResuscitationMechanical Circulatory Support DevicesARDSMedicineTidal volumeExtracorporealAnesthesiaMechanical ventilationVentilation (architecture)SedationLungSurgery

MeSH terms

AlgorithmsAnalgesicsFemaleHealth Status IndicatorsHumansHypercapniaHypnotics and SedativesIntensive Care UnitsMaleMiddle AgedPositive-Pressure RespirationProspective StudiesRespiratory Distress SyndromeTidal VolumeVentilator Weaning
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Lower tidal volume strategy (≈3 ml/kg) combined with extracorporeal CO2 removal versus ‘conventional’ protective ventilation (6 ml/kg) in severe ARDS · Scinovex