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Lower tidal volume strategy (≈3 ml/kg) combined with extracorporeal CO2 removal versus ‘conventional’ protective ventilation (6 ml/kg) in severe ARDS
Intensive Care Medicine · 2013 · Vol. 39(5) · pp. 847–856
Thomas Bein✉(University Hospital Regensburg)Steffen Weber‐Carstens(Charité - Universitätsmedizin Berlin)Anton Goldmann(Charité - Universitätsmedizin Berlin)Thomas Müller(University Hospital Regensburg)Thomas Staudinger(Medical University of Vienna)Jörg Brederlau(Helios Hospital Berlin-Buch)Ralf M. Muellenbach(University of Würzburg)Rolf Dembinski(RWTH Aachen University)Bernhard Gräf(University Hospital Regensburg)Marlene Wewalka(Vienna General Hospital)Alois Philipp(University Hospital Regensburg)Klaus‐Dieter Wernecke(Charité - Universitätsmedizin Berlin)Matthias Lubnow(University Hospital Regensburg)Arthur S. Slutsky(St. Michael's Hospital)
Abstract
The use of very low V(T) combined with extracorporeal CO2 removal has the potential to further reduce VILI compared with a 'normal' lung protective management. Whether this strategy will improve survival in ARDS patients remains to be determined (Clinical trials NCT 00538928).
Respiratory Support and MechanismsCardiac Arrest and ResuscitationMechanical Circulatory Support DevicesARDSMedicineTidal volumeExtracorporealAnesthesiaMechanical ventilationVentilation (architecture)SedationLungSurgery
MeSH terms
AlgorithmsAnalgesicsFemaleHealth Status IndicatorsHumansHypercapniaHypnotics and SedativesIntensive Care UnitsMaleMiddle AgedPositive-Pressure RespirationProspective StudiesRespiratory Distress SyndromeTidal VolumeVentilator Weaning
Citations
588
FWCI
43.83
field-weighted impact
References
33
Percentile
100%
vs. same field & year
Citations per year
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References
The American-European Consensus Conference On Ards. Definitions, Mechanisms, Relevant Outcomes, And Clinical Trial Coordination
American Journal of Respiratory and Critical Care Medicine · 1994 · 6,745 citations
Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome
New England Journal of Medicine · 2000 · 12,769 citations
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