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The mortality and pathology of HIV infection in a West African city
AIDS · 1993 · Vol. 7(12) · pp. 1569–1579
Sebastian Lucas✉(University College London)A. Hounnou✉(Santé Espoir Vie Côte d'Ivoire)Christopher S. Peacock✉(Santé Espoir Vie Côte d'Ivoire)A Beaumel(National Center for Infectious Diseases)Gaston Djomand✉(Santé Espoir Vie Côte d'Ivoire)Jean-Marie NʼGbichi(Santé Espoir Vie Côte d'Ivoire)Kouadio Yeboue✉(Santé Espoir Vie Côte d'Ivoire)M Hondé(National Center for Infectious Diseases)M Diomandé(National Center for Infectious Diseases)Christian Giordano(Centers for Disease Control and Prevention)Ronan Doorly✉(Santé Espoir Vie Côte d'Ivoire)Kari Brattegaard✉(Santé Espoir Vie Côte d'Ivoire)Luc Kestens(Instituut voor Tropische Geneeskunde)R W Smithwick(University College Hospital)A. Kadio(National Center for Infectious Diseases)Niamkey Ezani(National Center for Infectious Diseases)Achi Yapi(National Center for Infectious Diseases)Kevin M. De Cock✉(Centers for Disease Control and Prevention)
Abstract
In this population, HIV-positive adults present to hospital with advanced disease associated with high mortality. The three major underlying pathologies (TB, toxoplasmosis and bacteraemia) are either preventable or treatable. TB is an underestimated cause of the 'slim' syndrome in Africa. The patterns of pathology in HIV-2-positive patients suggest a more prolonged terminal course compared with HIV-1. There is an urgent need for attention towards the issues of therapy and care for HIV disease in developing countries.
Pneumocystis jirovecii pneumonia detection and treatmentHIV/AIDS Research and InterventionsTuberculosis Research and EpidemiologyMedicineTuberculosisAutopsyPneumoniaToxoplasmosisPopulationPediatricsImmunologyInternal medicinePathology
MeSH terms
AdolescentAdultAfrica, WesternBacterial InfectionsBrainCentral Nervous System DiseasesEncephalitisFemaleHumansLeukocyte CountMaleTuberculosisCD4-Positive T-LymphocytesHIV-1HIV-2
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