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Magnetic resonance imaging profiles predict clinical response to early reperfusion: The diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study

Annals of Neurology · 2006 · Vol. 60(5) · pp. 508–517

Gregory W. Albers✉(Stanford Medicine)Vincent Thijs(KU Leuven)Lawrence R. Wechsler(University of Pittsburgh)Stephanie Kemp(Stanford Medicine)Gottfried Schlaug(Harvard University)Elaine Skalabrin(University of Utah)Roland Bammer(Stanford Medicine)Wataru Kakuda(Stanford Medicine)Maarten G. Lansberg(Stanford Medicine)Ashfaq Shuaib(University of Alberta)William M. Coplin(University of Alberta)Scott Hamilton(Stanford Medicine)Michael E. Moseley(Stanford Medicine)Michael P. Marks(Stanford Medicine)

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Abstract

For stroke patients treated 3 to 6 hours after onset, baseline MRI findings can identify subgroups that are likely to benefit from reperfusion therapies and can potentially identify subgroups that are unlikely to benefit or may be harmed.

Acute Ischemic Stroke Management Cerebrovascular and Carotid Artery Diseases Stroke Rehabilitation and RecoveryMedicineMagnetic resonance imagingStroke (engine)Odds ratioThrombolysisTissue plasminogen activatorPerfusion scanningPerfusionClinical trialInternal medicine

MeSH terms

AgedBrainBrain IschemiaCerebrovascular CirculationFemaleFibrinolytic AgentsHumansMaleTissue Plasminogen ActivatorPredictive Value of TestsProspective StudiesSeverity of Illness IndexDisease ProgressionMagnetic Resonance AngiographyDiffusion Magnetic Resonance Imaging

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Guidelines for the Early Management of Patients With Acute Ischemic Stroke