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Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets
Organic & Biomolecular Chemistry · 2007 · Vol. 5(13) · pp. 2010–2010
Russell J. Cox✉(University of Bristol)
Abstract
Fungi produce a wide variety of biologically active compounds. Among these, the polyketides form a large and structurally diverse group. These compounds are synthesised by highly programmed and very large iterative multifunctional proteins, the polyketide synthases, with nm dimensions. This review outlines the current state of knowledge regarding the links between gene sequence, protein architecture and biosynthetic programming for fungal polyketide synthases.
Microbial Natural Products and BiosynthesisPlant Pathogens and Fungal DiseasesPlant-Microbe Interactions and ImmunityPolyketideGeneChemistryComputational biologySequence (biology)AscomycotaBiochemistryBiosynthesisBiology
MeSH terms
AnimalsFungal ProteinsGenes, FungalHumansPhylogenyMacrolidesPolyketide SynthasesNanostructures
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