articleTop 10% cited

Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines

Leukemia · 1997 · Vol. 11(10) · pp. 1605–1609

S Yokota✉(Kyoto Prefectural University of Medicine)Hitoshi Kiyoi(Nagoya University)Makoto Nakao(Kyoto Prefectural University of Medicine)Toshiki Iwai(Kyoto Prefectural University of Medicine)S Misawa(Kyoto Prefectural University of Medicine)Tsukasa Okuda(Kyoto Prefectural University of Medicine)Yukihiko Sonoda(Kyoto Prefectural University of Medicine)T Abe(Kyoto Prefectural University of Medicine)K Kahsima(Kyoto Prefectural University of Medicine)Yoshinobu Matsuo(Hayashibara (Japan))T Naoe(Nagoya University)

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Chronic Lymphocytic Leukemia Research Acute Myeloid Leukemia Research Chronic Myeloid Leukemia TreatmentsLeukemiaGene duplicationCancer researchMyeloid leukemiaTandem exon duplicationAcute lymphocytic leukemiaChronic lymphocytic leukemiaMyeloidLymphomaMedicine

MeSH terms

Acute DiseaseAdultAmino Acid SequenceBase SequenceDNA, NeoplasmHumansLeukemia, MyeloidMolecular Sequence DataMutationMyelodysplastic SyndromesProto-Oncogene ProteinsRepetitive Sequences, Nucleic AcidTumor Cells, CulturedProtein Structure, TertiaryHematologic Neoplasms

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Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis