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Dynamic regulation of genome-wide pre-mRNA splicing and stress tolerance by the Sm-like protein LSm5 in Arabidopsis

Genome biology · 2014 · Vol. 15(1) · pp. R1–R1

Peng Cui✉(King Abdullah University of Science and Technology)Shoudong Zhang(King Abdullah University of Science and Technology)Feng Ding(King Abdullah University of Science and Technology)Shahjahan Ali(King Abdullah University of Science and Technology)Liming Xiong(King Abdullah University of Science and Technology)

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Abstract

We conclude that SAD1 dynamically controls splicing efficiency and splice-site recognition in Arabidopsis, and propose that this may contribute to SAD1-mediated stress tolerance through the metabolism of transcripts expressed from stress-responsive genes. Our study not only provides novel insights into the function of Sm-like proteins in splicing, but also uncovers new means to improve splicing efficiency and to enhance stress tolerance in a higher eukaryote.

RNA Research and Splicing Plant Micronutrient Interactions and Effects RNA and protein synthesis mechanismsBiologyArabidopsisRNA splicingHuman geneticsComputational biologyGenomeGeneticsAlternative splicingMessenger RNAEvolutionary biology

MeSH terms

RNA PrecursorsStress, PhysiologicalSequence AlignmentRNA-Binding ProteinsGene DeletionArabidopsisAlternative SplicingSequence Analysis, RNAGene Expression Regulation, PlantRNA, PlantGene Expression ProfilingArabidopsis ProteinsSalt ToleranceGenetic Association Studies