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Structural basis of cyclin-dependent kinase activation by phosphorylation

Nature Structural & Molecular Biology · 1996 · Vol. 3(8) · pp. 696–700

Alicia A. Russo✉(Memorial Sloan Kettering Cancer Center)Philip D. Jeffrey(Memorial Sloan Kettering Cancer Center)Nikola P. Pavletich(Memorial Sloan Kettering Cancer Center)

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Cancer-related Molecular Pathways Enzyme Structure and Function Microtubule and mitosis dynamicsCyclin-dependent kinase 2Cyclin-dependent kinaseCyclin-dependent kinase complexPhosphorylationBiologyKinaseCell biologyCyclin ACyclin-dependent kinase 9Biochemistry

MeSH terms

Adenosine TriphosphateCrystallographyEnzyme ActivationModels, MolecularPhosphoproteinsPhosphorylationProtein ConformationCyclinsConserved SequenceProtein Serine-Threonine KinasesCyclin-Dependent KinasesCDC2-CDC28 KinasesCyclin-Dependent Kinase 2

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591

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Targeting Cyclin-Dependent Kinases in Human Cancers: From Small Molecules to Peptide Inhibitors

Cancers · 2015 · 340 citations

References

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

Journal of Applied Crystallography · 1991 · 14,142 citations

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