article Open AccessTop 10% cited
Mucosal healing and a fall in mucosal pro‐inflammatory cytokine mRNA induced by a specific oral polymeric diet in paediatric Crohn’s disease
Alimentary Pharmacology & Therapeutics · 2000 · Vol. 14(3) · pp. 281–289
Fell✉(Chelsea and Westminster Hospital)Paintin(Nestlé (Switzerland))Arnaud‐Battandier(Nestlé (France))R Mark Beattie(Peterborough City Hospital)Hollis(St Bartholomew's Hospital)Kitching(University College London)Donnet‐Hughes(Nestlé (Switzerland))MacDonald(St Bartholomew's Hospital)Walker‐Smith(The Royal Free Hospital)
Abstract
The clinical response to oral polymeric diet CT3211 is associated with mucosal healing and a down regulation of mucosal pro-inflammatory cytokine mRNA in both the terminal ileum and colon. In the ileum there was also an increase in transforming growth factor beta1 mRNA.
Inflammatory Bowel DiseaseIL-33, ST2, and ILC PathwaysMicroscopic ColitisIleumMedicineCytokineGastroenterologyCrohn's diseaseEnteral administrationInternal medicineInterleukinJejunumIntestinal mucosa
MeSH terms
AdolescentChildColonColonoscopyCrohn DiseaseEnteral NutritionFemaleFood, FormulatedHumansIleumIntestinal MucosaMaleRecurrenceRNA, MessengerTumor Necrosis Factor-alpha
Funding
- Nestec
Citations
412
FWCI
8.76
field-weighted impact
References
27
Percentile
98%
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Citations per year
Cited by
Guidelines for the management of inflammatory bowel disease in adults
Gut · 2011 · 1,432 citations
References
Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn’s disease LP cells manifest increased secretion of IFN-γ, whereas ulcerative colitis LP cells manifest increased secretion of IL-5
The Journal of Immunology · 1996 · 1,228 citations
Cross sectional stature and weight reference curves for the UK, 1990.
Archives of Disease in Childhood · 1995 · 1,472 citations
Body mass index reference curves for the UK, 1990.
Archives of Disease in Childhood · 1995 · 2,091 citations
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