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The Role of Cerebrospinal Fluid Hypocretin Measurement in the Diagnosis of Narcolepsy and Other Hypersomnias

Archives of Neurology · 2002 · Vol. 59(10) · pp. 1553–1553

Emmanuel Mignot✉(Stanford University)Gert Jan LammersBeth RipleyMichele L. OkunSoňa NevšímalováSebastiaan OvereemJitka VaňkováJed BlackJohn HarshClaudio L. BassettiH. SchraderSeiji Nishino

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Abstract

Narcolepsy-cataplexy with hypocretin deficiency is a genuine disease entity. Measuring CSF hypocretin-1 is a definitive diagnostic test, provided that it is interpreted within the clinical context. It may be most useful in cases with cataplexy and when the MSLT is difficult to interpret (ie, in subjects already treated with psychoactive drugs or with other concurrent sleep disorders).

Sleep and Wakefulness Research Sleep and related disorders Regulation of Appetite and ObesityNarcolepsyCataplexyMultiple Sleep Latency TestOrexinNeurologySleep disorderMedicinePolysomnographyCerebrospinal fluidInternal medicine

MeSH terms

OrexinsAdultCarrier ProteinsDiagnosis, DifferentialFemaleHistocompatibility TestingHLA-DQ AntigensHumansMaleMembrane GlycoproteinsMiddle AgedNarcolepsyNeuropeptidesSensitivity and SpecificitySympathomimetics

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