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Antimycobacterial Activity of Prenylated Xanthones from the Fruits of Garcinia mangostana
Chemical and Pharmaceutical Bulletin · 2003 · Vol. 51(7) · pp. 857–859
Sunit Suksamrarn✉(Srinakharinwirot University)Narisara Suwannapoch(Srinakharinwirot University)Wong Phakhodee(Srinakharinwirot University)Janthana Thanuhiranlert(Srinakharinwirot University)Piniti Ratananukul(Srinakharinwirot University)Nitirat Chimnoi(Chulabhorn Research Institute)Apichart Suksamrarn(Ramkhamhaeng University)
Abstract
Prenylated xanthones, isolated from the fruit hulls and the edible arils and seeds of Garcinia mangostana, were tested for their antituberculosis potential. Alpha- and beta-mangostins and garcinone B exhibited strong inhibitory effect against Mycobacterium tuberculosis with the minimum inhibitory concentration (MIC) value of 6.25 microg/ml. Tri- and tetra-oxygenated xanthones with di-C5 units or with a C5 and a modified C5 groups are essential for high activities. Substitution in the A and C rings has been shown to modify the bioactivity of the compounds.
Natural Compound Pharmacology StudiesSynthesis of Organic CompoundsGarcinia mangostanaAntimycobacterialChemistryXanthoneArilGarciniaPrenylationMinimum inhibitory concentrationStereochemistryTraditional medicine
MeSH terms
Anti-Bacterial AgentsFruitMicrobial Sensitivity TestsProtein PrenylationGarcinia mangostanaXanthones
Funding
- Thailand Research Fund
Citations
259
FWCI
4.18
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20
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93%
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References
Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium
Antimicrobial Agents and Chemotherapy · 1997 · 1,597 citations
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