article Open AccessTop 1% cited
The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
Nature Protocols · 2007 · Vol. 2(2) · pp. 322–328
Alicia A. Walf✉(University at Albany, State University of New York)Cheryl A. Frye(University at Albany, State University of New York)
Stress Responses and CortisolNeuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on BehaviorElevated plus mazeAnxietyRodentNeuroscienceAnimal behaviorLocomotor activityPsychologyMedicineInternal medicineBiology
MeSH terms
AnimalsAnxietyData CollectionExploratory BehaviorObservationMiceRats
Funding
- National Science Foundation
- U.S. Department of Defense
- National Institute of Mental Health
Citations
2,940
FWCI
8.15
field-weighted impact
References
79
Percentile
99%
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Citations per year
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References
A multiple-test study of anxiety-related behaviours in six inbred rat strains
Behavioural Brain Research · 1997 · 501 citations
Measuring normal and pathological anxiety-like behaviour in mice: a review
Behavioural Brain Research · 2001 · 914 citations
Anxiety, defence and the elevated plus-maze
Neuroscience & Biobehavioral Reviews · 1997 · 984 citations
Sex differences in animal tests of anxiety
Physiology & Behavior · 1991 · 588 citations
Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3α,5α-THP
Pharmacology Biochemistry and Behavior · 2000 · 442 citations
Estrous cycle influences the response of female rats in the elevated plus-maze test
Physiology & Behavior · 2001 · 451 citations
Anxiogenic stimuli in the elevated plus-maze
Pharmacology Biochemistry and Behavior · 1993 · 619 citations
The use of a plus-maze to measure anxiety in the mouse
Psychopharmacology · 1987 · 2,598 citations
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