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Design, Synthesis and Evaluation of Antiinflammatory, Analgesic and Ulcerogenicity studies of Novel S-Substituted phenacyl-1,3,4-oxadiazole-2-thiol and Schiff bases of Diclofenac acid as Nonulcerogenic Derivatives

Bioorganic & Medicinal Chemistry · 2007 · Vol. 16(4) · pp. 1822–1831
Synthesis and biological activityInflammatory mediators and NSAID effectsSynthesis and Reactions of Organic CompoundsDiclofenac SodiumChemistryDiclofenacAnalgesicPhenacylCarrageenanAcetic acidAnti-inflammatoryMoietyPharmacology

MeSH terms

AnimalsAnti-Inflammatory Agents, Non-SteroidalDiclofenacDrug Evaluation, PreclinicalOxadiazolesSchiff BasesStomach UlcerStructure-Activity RelationshipSulfhydryl CompoundsDrug DesignAnalgesics, Non-NarcoticRats

Funding

  • Analytical Center for the Government of the Russian Federation
Citations
300
FWCI
5.78
field-weighted impact
References
28
Percentile
97%
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